SIMULTANEOUS ELEVATION OF THE LEVELS OF CIRCULATING MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND TISSUE FACTOR IN ACUTE CORONARY SYNDROMES

Authors
NISHIYAMA K OGAWA H YASUE H SOEJIMA H MISUMI K TAKAZOE K YOSHIMURA M KUGIYAMA K TSUJI I KUMEDA K
Citation
K. Nishiyama et al., SIMULTANEOUS ELEVATION OF THE LEVELS OF CIRCULATING MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND TISSUE FACTOR IN ACUTE CORONARY SYNDROMES, Japanese Circulation Journal, 62(9), 1998, pp. 710-712
Citations number
10
Categorie Soggetti
Peripheal Vascular Diseas
Journal title
Japanese Circulation Journal → ACNP
ISSN journal
00471828
Volume
62
Issue
9
Year of publication
1998
Pages
710 - 712
Database
ISI
SICI code
0047-1828(1998)62:9<710:SEOTLO>2.0.ZU;2-B
Abstract
The levels of circulating monocyte chemoattractant protein-1 (MCP-I) a nd tissue factor (TF) were examined on admission in 46 consecutive pat ients with acute coronary syndromes (ACS) and 30 patients with stable exertional angina (SEA). The plasma levels of both MCP-1 and TF were h igher in the ACS patients than in the SEA patients (MCP-1: p<0.001; TF : p<0.001). Only the circulating TF level related to the number of dis eased vessels. A positive correlation between plasma MCP-I and TF leve ls was found (r=0.476, p<0.001). These results suggest that circulatin g MCP-1 plays an important role in the pathogenesis and/or development of ACS.