A NOVEL MONOCLONAL-ANTIBODY 107-1A4 WITH HIGH PROSTATE SPECIFICITY - GENERATION, CHARACTERIZATION OF ANTIGEN EXPRESSION, AND TARGETING OF HUMAN PROSTATE-CANCER XENOGRAFTS

Authors
BROWN LG WEGNER SK WANG H BUHLER KR ARFMAN EW LANGE PH VESSELLA RL
Citation
Lg. Brown et al., A NOVEL MONOCLONAL-ANTIBODY 107-1A4 WITH HIGH PROSTATE SPECIFICITY - GENERATION, CHARACTERIZATION OF ANTIGEN EXPRESSION, AND TARGETING OF HUMAN PROSTATE-CANCER XENOGRAFTS, PROSTATE CANCER AND PROSTATIC DISEASES, 1(4), 1998, pp. 208-215
Citations number
24
Categorie Soggetti
Oncology,"Urology & Nephrology
Journal title
PROSTATE CANCER AND PROSTATIC DISEASES → ACNP
ISSN journal
13657852
Volume
1
Issue
4
Year of publication
1998
Pages
208 - 215
Database
ISI
SICI code
1365-7852(1998)1:4<208:ANM1WH>2.0.ZU;2-6
Abstract
Monoclonal antibodies with high specificity for prostate tissue are of interest for prostate cancer research and treatment. Reactivity and s pecificity of a new murine monoclonal antibody, 107-1A4, was assessed by immunohistochemistry, ELISA and indirect immunofluorescence (IDIF). 107-1A4 stained all normal and malignant prostate tissue specimens wh ile reactivity to non-prostate tissue was limited to the tubules of th e normal kidney and renal cell carcinoma. Twenty two human cell lines were included in the reactivity survey; only the immunogen prostate ca ncer line LNCaP reacted with 107-1A4. Seminal plasma proteins PSA, PAP , PSMA, and PSP-94 were determined not to be the 107-1A4 antigen.