CHLORIDE CHANNELS CLC-2 AND ICLN MESSENGER-RNA EXPRESSION DIFFERS IN RENAL EPITHELIAL ONTOGENY

Authors
HUBER S BRAUN G SCHROPPEL B HORSTER M
Citation
S. Huber et al., CHLORIDE CHANNELS CLC-2 AND ICLN MESSENGER-RNA EXPRESSION DIFFERS IN RENAL EPITHELIAL ONTOGENY, Kidney international, 54, 1998, pp. 149-151
Citations number
8
Categorie Soggetti
Urology & Nephrology
Journal title
Kidney international → ACNP
ISSN journal
00852538
Volume
54
Year of publication
1998
Supplement
67
Pages
149 - 151
Database
ISI
SICI code
0085-2538(1998)54:<149:CCCAIM>2.0.ZU;2-S
Abstract
Development-dependent mRNA expression of the chloride channels ClC-2 a nd ICln was studied by quantitative reverse transcriptase-polymerase c hain reaction in rat ureteric bud and cortical collecting duct primary monolayer cultures. Abundance of ClC-2 mRNA increased in ureteric bud cells between embryonic day 15 (E15) and E17, peaked at postnatal day 3 (P3), and was down-regulated at P7 when morphogenesis is complete, suggesting a specific embryonic function. Expression of ICln mRNA, in contrast, up-regulated continuously with development.