COMBINED ANALYSIS OF 2 MULTICENTER STUDIES OF FINASTERIDE 5 MG IN THETREATMENT OF SYMPTOMATIC BENIGN PROSTATIC HYPERPLASIA

The purpose of this paper is to examine effects of finasteride 5 mg ac ross different age groups in an ethnically diverse population of men w ith symptomatic benign prostatic hyperplasia (BPH) seen in community u rology and primary care practices. Data were combined from two previou s placebo-controlled randomised trials of finasteride that evaluated c hanges in urinary symptoms, blinded global assessments of urologic sta tus, adverse experiences, and effects on dihydrotestosterone (DHT) and prostate-specific antigen (PSA) in over 4500 men. Finasteride showed a favourable efficacy and tolerability profile in this large ethnicall y diverse population and was similarly effective in middle-aged and ol der men with BPH and prostate gland enlargement.