PREVALENCE OF PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN) IN BIOPSIES FROM HOSPITAL PRACTICE AND PILOT SCREENING - CLINICAL IMPLICATIONS

As high grade PIN is commonly associated with concomitant cancer, curr ent literature recommends re-biopsy of patients with high grade PIN. T his paper describes the prevalence of high grade prostatic intra-epith elial neoplasia (PIN) from three independent clinical settings, report ed by a single pathologist (MCP). High grade PIN was diagnosed in biop sies from 131 of the 1205 (11%) of patients in whom cancer was suspect ed in hospital practice, 42 of the 202 (20%) asymptomatic men screened for prostate cancer and 29 of the 118 (25%) patients presenting with prostatism in a case finding study. Re-biopsy on this scale has major clinical and cost implications. However, from a literature review, the re is evidence to suggest that the risk of concomitant cancer with hig h grade PIN may be stratified according to serum PSA. This opinion sho uld be tested prospectively.