DAY-TO-DAY CHANGES IN FREE AND TOTAL PSA - SIGNIFICANCE OF BIOLOGICALVARIATION

Citation
Rg. Nixon et al., DAY-TO-DAY CHANGES IN FREE AND TOTAL PSA - SIGNIFICANCE OF BIOLOGICALVARIATION, PROSTATE CANCER AND PROSTATIC DISEASES, 1(2), 1997, pp. 90-96
Citations number
22
Categorie Soggetti
Oncology,"Urology & Nephrology
ISSN journal
13657852
Volume
1
Issue
2
Year of publication
1997
Pages
90 - 96
Database
ISI
SICI code
1365-7852(1997)1:2<90:DCIFAT>2.0.ZU;2-E
Abstract
In this study we evaluated the physiological variation of free and tot al prostate-specific antigen (PSA) levels to determine how the percent free/total PSA was affected. Twenty four patients had blood drawn for ten consecutive weekdays. The percent coefficient of variation (% CV) of biological variation was calculated. The results were log-normally distributed with geometric means of 12.0% CV, 7.3% CV, and 8.8% CV fo r free, total, and percent free/total PSA, respectively. When applied, the percent free/total, PSA would need to fluctuate by 31% to indicat e that a significant change (critical difference, P<0.05) between two measurements had occurred. Biological variation of PSA measurements is substantial.