Ki. Cheng et al., ANESTHESIA FOR PEDIATRIC HERNIORRHAPHY OR HYDROCELECTOMY - COMPARISONOF PROPOFOL KETAMINE AND THIOPENTONE/HALOTHANE/, Journal of the Formosan Medical Association, 97(8), 1998, pp. 557-563
Total intravenous anesthesia has recently become available for ambulat
ory surgery. It has the advantages of decreased air contamination from
volatile anesthetics and decreased exposure of operating room personn
el to volatile anesthetics. The purpose of this study was to compare t
he anesthetic properties of propofol/ketamine (total intravenous) anes
thesia and thiopentone/halothane (intravenous and gaseous) anesthesia
for herniorrhaphy or hydrocelectomy in children. Sixty children aged 2
to 7 years scheduled for herniorrhaphy or hydrocelectomy were allocat
ed to two groups. The propofol/ketamine group (group 1) received a. lo
ading dose of intravenous propofol 3 mg/kg followed by propofol infusi
on 200 mu g/kg/minute; additional bolus doses of propofol 1 mg/kg were
given as needed or the infusion dose was increased or decreased by 33
mu g/kg/minute as needed. Ketamine 1 mg/kg was administered intraveno
usly 2 to 3 minutes before herniorrhaphy or hydrocelectomy to reinforc
e the analgesic and anesthetic effects of propofol. The thiopentone/ha
lothane group (group 2) received intravenous thiopentone 6 mg/kg follo
wed by halothane with 40% oxygen using a mask. Group 2 patients mainta
ined spontaneous breathing with intermittent assistance and group 1 pa
tients maintained spontaneous natural airway breathing during anesthes
ia. The scores on the postoperative assessment scale were higher in gr
oup 2 patients, indicating poorer anesthesia recovery characteristics,
but the differences were not significant. Pain on injection was more
frequent in group 1 (12/32) than in group 2 (2/28). The incidence of v
omiting in group 2 (6/28) was significantly higher than in group (0/32
). We conclude that propofol/ketamine allows patients to maintain spon
taneous natural airway breathing during anesthesia, and its analgesic
and anesthetic effects are comparable to those of thiopentone/halothan
e. Propofol/ketamine is appropriate for pediatric herniorrhaphy and hy
drocelectomy. It can be recommended for pediatric ambulatory surgery.