POLYMORPHONUCLEAR PHAGOCYTOSIS AND KILLING IN WORKERS OCCUPATIONALLY EXPOSED TO HEXACHLOROBENZENE

Authors
QUEIROZ MLS QUADROS MR VALADARES MC SILVEIRA JP
Citation
Mls. Queiroz et al., POLYMORPHONUCLEAR PHAGOCYTOSIS AND KILLING IN WORKERS OCCUPATIONALLY EXPOSED TO HEXACHLOROBENZENE, Immunopharmacology and immunotoxicology, 20(3), 1998, pp. 447-454
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,Toxicology
Journal title
Immunopharmacology and immunotoxicology → ACNP
ISSN journal
08923973
Volume
20
Issue
3
Year of publication
1998
Pages
447 - 454
Database
ISI
SICI code
0892-3973(1998)20:3<447:PPAKIW>2.0.ZU;2-E
Abstract
Phagocytosis and intracellular killing of Candida albicans and Candida pseudotropicalis by neutrophils from 66 workers exposed to chlorinate d compounds were studied. Phagocytosis with both antigens was normal i n all the workers studied. However, lytic activity of the neutrophils in the presence of both antigens, C. albicans and C. pseudotropicalis was impaired. These findings might be related to a derangement in the antioxidant mechanisms and to some interference with GSH levels that m ight lead to the abnormal functions observed in neutrophils.