CHARACTERIZATION OF POLYMORPHISMS AT THE 11-BETA-HYDROXYLASE (CYP11B1) LOCUS

Authors
SKINNER CA YOUSAF N HONOUR JW RUMSBY G
Citation
Ca. Skinner et al., CHARACTERIZATION OF POLYMORPHISMS AT THE 11-BETA-HYDROXYLASE (CYP11B1) LOCUS, Annals of Human Genetics, 62, 1998, pp. 181-183
Citations number
10
Categorie Soggetti
Genetics & Heredity
Journal title
Annals of Human Genetics → ACNP
ISSN journal
00034800
Volume
62
Year of publication
1998
Part
2
Pages
181 - 183
Database
ISI
SICI code
0003-4800(1998)62:<181:COPAT1>2.0.ZU;2-0
Abstract
Four sequence variants in the 11 beta-hydroxylase (CYP11B1) gene are r eported. One of the sequence changes occurs in exon 1 and is in linkag e disequilibrium with a second variant in intron 3. The other two chan ges occur at adjacent nucleotides in intron 1. The finding of easily d emonstrable, intragenic variants will be beneficial to the study of th e role of the CYP11B1 and the adjacent aldosterone synthase (CYP11B2) gene in hypertensive disease.