CLEAR-CELL ODONTOGENIC-TUMOR IN THE MANDIBLE - REPORT OF A CASE WITH AN IMMUNOHISTOCHEMICAL STUDY OF EPITHELIAL-CELL MARKERS

A rare case of clear cell odontogenic tumor is presented with an immun ohistochemical study using epithelial cell markers. A 35-year-old Japa nese man was admitted with a complaint of painless swelling in the ant erior region of his mandible. Radiological examination showed a relati vely well-defined multilocular radiolucency with root resorption of th e adjacent teeth. Despite a subtotal mandibulectomy, the tumor recurre d three times. Histologically, the tumor was composed of proliferating clear cells and infiltrated through the cancellous bone. Histochemica l and ultrastructural analyses detected cytoplasmic glycogen granules in the clear cells. They showed immunoreactivities for cytokeratin 8, 13 and 19, filaggrin and anti-ameloblastoma antibodies, suggesting an odontogenic epithelial origin.