P. Mackowiak et al., THE INFLUENCE OF THE KALLIKREIN-KININ SYSTEM ON THE CHARACTERISTICS OF INSULIN-RECEPTORS IN RAT SKELETAL-MUSCLE DURING ISCHEMIA, Journal of Animal and Feed Sciences, 7(1), 1998, pp. 93-101
To investigate the role of kinins in ischemia, bradykinin and kininase
II inhibitor (captopril) were injected to rats with acute ischemia of
the hind limb. Maximum specific binding (Bsp%) of insulin to hind lim
b muscle membranes as well as the number of insulin receptors were inv
estigated. In ischemic rats glucose turnover was disturbed and its inc
reased concentration in blood together with lowered binding of insulin
were observed. Bradykinin and captopril normalized the glucose level,
increasing insulin binding to membranes. Simultaneously, they elevate
d the number of low-affinity insulin receptors in muscle membranes of
ischemic rats. In the light of the obtained results bradykinin and cap
topril seem to improve disturbed carbohydrate metabolism by affecting
the number of insulin binding sites in muscles.