USE OF A MODIFIED NONLINEAR MAPPING METHOD IN QUANTITATIVE STRUCTURE-RETENTION RELATIONSHIP STUDY

The interaction of 20 nonsteroidal anti-inflammatory drugs with a mode l protein was studied by reversed-phase highperformance liquid chromat ography and the relationship between the strength of interaction and t he physicochemical. parameters of drugs was elucidated by principal co mponent analysis followed by modified nonlinear mapping and cluster an alysis. It was established that the polarity and and sterical paramete rs of drugs exert the highest influence on the interaction. Cluster an alysis and nonlinear mapping using the absolute values of principal co mponent loadings explain more precisely the interaction than the tradi tional nonlinear mapping and cluster analysis do.