SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF BENZOFURAN-ACETAMIDES AS ANTINEOPHOBIC MITOCHONDRIAL DBI RECEPTOR COMPLEX LIGANDS

Authors
LIAO Y KOZIKOWSKI AP GUIDOTTI A COSTA E
Citation
Y. Liao et al., SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF BENZOFURAN-ACETAMIDES AS ANTINEOPHOBIC MITOCHONDRIAL DBI RECEPTOR COMPLEX LIGANDS, Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2099-2102
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
16
Year of publication
1998
Pages
2099 - 2102
Database
ISI
SICI code
0960-894X(1998)8:16<2099:SAPEOB>2.0.ZU;2-9
Abstract
A series of novel benzofuran analogues of N,N-di-n-hexyl-2-phenylindol e-3-acetamide (5, FGIN-1-27), a potent and highly specific mitochondri al DBI receptor complex ligand, were synthesized by a modified Fischer method and found in vitro and in vivo to be equally potent and select ive as FGIN-1-27. (C) 1998 Elsevier Science Ltd. All rights reserved.