EFFECTS OF PHOSPHOROTHIOATE OLIGODEOXYRIBONUCLEOTIDE AND OLIGORIBONUCLEOTIDES ON HUMAN-COMPLEMENT AND COAGULATION

Authors
KANDIMALLA ER SHAW DR AGRAWAL S
Citation
Er. Kandimalla et al., EFFECTS OF PHOSPHOROTHIOATE OLIGODEOXYRIBONUCLEOTIDE AND OLIGORIBONUCLEOTIDES ON HUMAN-COMPLEMENT AND COAGULATION, Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2103-2108
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
16
Year of publication
1998
Pages
2103 - 2108
Database
ISI
SICI code
0960-894X(1998)8:16<2103:EOPOAO>2.0.ZU;2-W
Abstract
We have synthesized and studied the effects of phosphorothioate (PS) o ligodeoxyribonucleotide (DNA) and oligoribonucleotides (RNA, 2'-O-meth yl-RNA and 2'-5'-RNA) on complement activation and prolongation of act ivated partial thromboplastin time (aPTT) in vitro. These results sugg est that a PS-DNA prolongs aPTT, and inhibits complement lysis more th an do the PS-RNA analogs. (C) 1998 Elsevier Science Ltd. All rights re served.