SYNTHESIS OF NOVEL SUBSTITUTED PYRIDINES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME-1 (ECE-1)

Authors
MASSA MA PATT WC AHN K SISNEROS AM HERMAN SB DOHERTY A
Citation
Ma. Massa et al., SYNTHESIS OF NOVEL SUBSTITUTED PYRIDINES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME-1 (ECE-1), Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2117-2122
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
16
Year of publication
1998
Pages
2117 - 2122
Database
ISI
SICI code
0960-894X(1998)8:16<2117:SONSPA>2.0.ZU;2-S
Abstract
A series of bi-aryl pyridine carboxylic acids has been prepared and ev aluated as inhibitors of ECE-1. The analogs were prepared by Pd cataly zed cross couplings of halogenated pyridines with heteroaryl organo -b oranes, -tinate or -zincate derivatives. (C) 1998 Elsevier Science Ltd . All rights reserved.