Ma. Massa et al., SYNTHESIS OF NOVEL SUBSTITUTED PYRIDINES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME-1 (ECE-1), Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2117-2122
A series of bi-aryl pyridine carboxylic acids has been prepared and ev
aluated as inhibitors of ECE-1. The analogs were prepared by Pd cataly
zed cross couplings of halogenated pyridines with heteroaryl organo -b
oranes, -tinate or -zincate derivatives. (C) 1998 Elsevier Science Ltd
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