THE CHOLESTEROL METABOLITE CHOLEST-4-EN-3-ONE AND ITS 3-OXO DERIVATIVES SUPPRESS BODY-WEIGHT GAIN, BODY-FAT ACCUMULATION AND SERUM-LIPID CONCENTRATION IN MICE

Authors
SUZUKI K SHIMIZU T NAKATA T
Citation
K. Suzuki et al., THE CHOLESTEROL METABOLITE CHOLEST-4-EN-3-ONE AND ITS 3-OXO DERIVATIVES SUPPRESS BODY-WEIGHT GAIN, BODY-FAT ACCUMULATION AND SERUM-LIPID CONCENTRATION IN MICE, Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2133-2138
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
16
Year of publication
1998
Pages
2133 - 2138
Database
ISI
SICI code
0960-894X(1998)8:16<2133:TCMCAI>2.0.ZU;2-R
Abstract
Based on the findings that cholest-4-en-3-one, an intestinal metabolit e of cholesterol, has an anti-obesity effect on animals, the structure -effect relationship of its 3-oxo derivatives and related compounds we re investigated. Cholesten-3-ones, which possesses an enone structure with a carbonyl group at C3, markedly inhibit body weight gain and bod y fat accumulation, as well as the levels of serum triglyceride and ch olesterol in animals without any clinical abnormalities. (C) 1998 Else vier Science Ltd. All rights reserved.