A DIPYRIDO[2,3-B 3',2'-F]AZEPINE ANALOG OF THE HIV-1 REVERSE-TRANSCRIPTASE INHIBITOR NEVIRAPINE/

Authors
DYATKIN AB BRICKWOOD JR PROUDFOOT JR
Citation
Ab. Dyatkin et al., A DIPYRIDO[2,3-B 3',2'-F]AZEPINE ANALOG OF THE HIV-1 REVERSE-TRANSCRIPTASE INHIBITOR NEVIRAPINE/, Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2169-2172
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
16
Year of publication
1998
Pages
2169 - 2172
Database
ISI
SICI code
0960-894X(1998)8:16<2169:AD3AOT>2.0.ZU;2-6
Abstract
The syntheses of 11-ethyl and 11-cyclopropyldipyrido[2,3-b:3',2'-f]aze pines analogs of the HIV-1 reverse transcriptase inhibitor nevirapine 1, are described. :These compounds exhibit potency equivalent to nevir apine in the inhibition of wild-type and some mutant RT enzymes. (C) 1 998 Elsevier Science Ltd. All rights reserved.