CONFORMATIONALLY RESTRICTED ANALOGS OF NICOTINE AND ANABASINE

Authors
VERNIER JM HOLSENBACK H COSFORD NDP WHITTEN JP MENZAGHI F REID R RAO TS SACAAN AI LLOYD GK SUTO CM CHAVEZNORIEGA LE WASHBURN MS URRUTIA A MCDONALD IA
Citation
Jm. Vernier et al., CONFORMATIONALLY RESTRICTED ANALOGS OF NICOTINE AND ANABASINE, Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2173-2178
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
16
Year of publication
1998
Pages
2173 - 2178
Database
ISI
SICI code
0960-894X(1998)8:16<2173:CRAONA>2.0.ZU;2-B
Abstract
A series of conformationally restricted analogues of nicotine has been synthesized and evaluated as agonists of neuronal acetylcholine recep tors. Compound 2 (SIB-1663), which selectively activated human recombi nant alpha 2 beta 4 and alpha 4 beta 4 nAChRs, was shown to be active in animal models of Parkinson's disease and pain, (C) 1998 Elsevier Sc ience Ltd. All rights reserved.