REACTIONS OF 7-AMINOADENINES AND 9-AMINOADENINES WITH 2,4-PENTANEDIONE - FORMATION OF NEW RING-SYSTEMS, PYRIDAZINO[6,1-F]PURINE AND PYRIDAZINO[1,6-E]PURINE

Authors
KAIYA T SAGA T YAMAGATA Y KOHDA K
Citation
T. Kaiya et al., REACTIONS OF 7-AMINOADENINES AND 9-AMINOADENINES WITH 2,4-PENTANEDIONE - FORMATION OF NEW RING-SYSTEMS, PYRIDAZINO[6,1-F]PURINE AND PYRIDAZINO[1,6-E]PURINE, Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2197-2202
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
16
Year of publication
1998
Pages
2197 - 2202
Database
ISI
SICI code
0960-894X(1998)8:16<2197:RO7A9W>2.0.ZU;2-P
Abstract
Reactions of 7-aminoadenines with 2,4-pentanedione yielded pyridazino[ 6,1-f]purines and 5-pyrazolylpyrimidines. The structure of the latter was identified by X-ray analysis. Reaction of 9-amino-N-6-methyladenin e with 2,4-pentanedione gave pyridazino[1,6-e]purine and Schiff base p roducts. Possible reaction mechanisms are discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.