A SIMPLE PROCEDURE FOR SOLID-PHASE SYNTHESIS OF PEPTIDE NUCLEIC-ACIDSWITH N-TERMINAL CYSTEINE

Authors
GOODWIN TE HOLLAND RD LAY JO RANEY KD
Citation
Te. Goodwin et al., A SIMPLE PROCEDURE FOR SOLID-PHASE SYNTHESIS OF PEPTIDE NUCLEIC-ACIDSWITH N-TERMINAL CYSTEINE, Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2231-2234
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
16
Year of publication
1998
Pages
2231 - 2234
Database
ISI
SICI code
0960-894X(1998)8:16<2231:ASPFSS>2.0.ZU;2-D
Abstract
Problems were encountered during attempts to prepare N-terminal cystei ne-substituted peptide nucleic acids (PNAs) from commercially availabl e, Fmoc-protected monomers. These problems have been surmounted by the use of an S-t-butylmercapto protecting group on the cysteine moiety. The solid-phase syntheses are carried out via a simplified procedure w hich should be generally useful for manual PNA synthesis. (C) 1998 Els evier Science Ltd. All rights reserved.