L-TRYPTOPHAN UREA AMIDES AS NK1 NK2 DUAL ANTAGONISTS/

Authors
QI HB SHAH SK CASCIERI MA SADOWSKI SJ MACCOSS M
Citation
Hb. Qi et al., L-TRYPTOPHAN UREA AMIDES AS NK1 NK2 DUAL ANTAGONISTS/, Bioorganic & medicinal chemistry letters, 8(16), 1998, pp. 2259-2262
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
16
Year of publication
1998
Pages
2259 - 2262
Database
ISI
SICI code
0960-894X(1998)8:16<2259:LUAANN>2.0.ZU;2-W
Abstract
We report that a systematic modification of an NK1 receptor selective antagonist resulted in the identification of novel compounds, 4c and 4 d, with high affinity for both NK1 and NK2 receptors. (C) 1998 Elsevie r Science Ltd. All rights reserved.