EVALUATION OF A SULFOBUTYL ETHER BETA-CYCLODEXTRIN AS A SOLUBILIZING STABILIZING AGENT FOR SEVERAL DRUGS/

To evaluate the potential use of beta-cyclodextrin sulfobutyl ether; 7 sodium salt (SBE7-beta-CD) as a drug solubilizing and stabilizing age nt, the solubilizing effects of SBE7-beta-CD on 22 different poorly wa ter-soluble drugs were compared with those of intact beta-CD and hepta kis-(2,6-di-O-methyl)-beta-CD (DMCD). SBE7-beta-CD was generally a mor e effective solubilizer for poorly water-soluble drugs than was intact beta-CD, but SBE7-beta-CD was not as effective as DMCD. The effects o f SBE7-beta-CD on the acid hydrolysis rate of prostaglandin I-2, the a lkaline hydrolysis rare of indomethacin, the dehydration of prostaglan din E-1, and the isomerization of prostaglandin A(1) were also investi gated and compared to those far intact beta-CD, DMCD, and 2,3,6 partia lly methylated-beta-CD (PMCD). The stabilizing effects of SBE7-beta-CD on chemically unstable drugs were generally higher than chose of othe r CDs.