H. Ueda et al., EVALUATION OF A SULFOBUTYL ETHER BETA-CYCLODEXTRIN AS A SOLUBILIZING STABILIZING AGENT FOR SEVERAL DRUGS/, Drug development and industrial pharmacy, 24(9), 1998, pp. 863-867
To evaluate the potential use of beta-cyclodextrin sulfobutyl ether; 7
sodium salt (SBE7-beta-CD) as a drug solubilizing and stabilizing age
nt, the solubilizing effects of SBE7-beta-CD on 22 different poorly wa
ter-soluble drugs were compared with those of intact beta-CD and hepta
kis-(2,6-di-O-methyl)-beta-CD (DMCD). SBE7-beta-CD was generally a mor
e effective solubilizer for poorly water-soluble drugs than was intact
beta-CD, but SBE7-beta-CD was not as effective as DMCD. The effects o
f SBE7-beta-CD on the acid hydrolysis rate of prostaglandin I-2, the a
lkaline hydrolysis rare of indomethacin, the dehydration of prostaglan
din E-1, and the isomerization of prostaglandin A(1) were also investi
gated and compared to those far intact beta-CD, DMCD, and 2,3,6 partia
lly methylated-beta-CD (PMCD). The stabilizing effects of SBE7-beta-CD
on chemically unstable drugs were generally higher than chose of othe
r CDs.