REGIONAL CHROMOSOMAL ASSIGNMENT OF THE KELL BLOOD-GROUP LOCUS (KEL) TO CHROMOSOME 7Q33-Q35 BY FLUORESCENCE IN-SITU HYBRIDIZATION - EVIDENCEFOR THE POLYPEPTIDE NATURE OF ANTIGENIC VARIATION

Authors
MURPHY MT MORRISON N MILES JS FRASER RH SPURR NK BOYD E
Citation
Mt. Murphy et al., REGIONAL CHROMOSOMAL ASSIGNMENT OF THE KELL BLOOD-GROUP LOCUS (KEL) TO CHROMOSOME 7Q33-Q35 BY FLUORESCENCE IN-SITU HYBRIDIZATION - EVIDENCEFOR THE POLYPEPTIDE NATURE OF ANTIGENIC VARIATION, Human genetics, 91(6), 1993, pp. 585-588
Citations number
25
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
91
Issue
6
Year of publication
1993
Pages
585 - 588
Database
ISI
SICI code
0340-6717(1993)91:6<585:RCAOTK>2.0.ZU;2-2
Abstract
The gene encoding the Kell blood group polypeptide has been localized to chromosome 7q33-35 by in situ hybridization using a biotinylated 1. 1-kb DNA fragment containing the 3' half of the human cDNA. This assig nment is in accord with genetic localization using antigenic variation as a marker, and strongly suggests that Kell antigenic determinants a re part of the polypeptide chain rather than the associated sugar mole cules.