ICELANDIC FAMILIES WITH AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY-DISEASE - FAMILIES UNLINKED TO CHROMOSOME 16P13.3 REVEALED BY LINKAGE ANALYSIS

We have mainly used 3 highly polymorphic DNA markers, 3'HVR (D16S85), 16AC2.5 (D16S291) and SM7 (D16S283), flanking the PKD1 region on chrom osome 16p13.3 to establish linkage status in seven Icelandic families with autosomal dominant polycystic kidney disease (ADPKD). In four fam ilies, the disease locus is in the PKD1 region, and three families are ''unlinked'' to chromosome 16p13.3. In one of the ''unlinked'' famili es, the disease locus is excluded from a part of the long arm of chrom osome 2, and we support a theory of more than 2 loci being responsible for ADPKD. Our data confirm the location of the locus YNH24 (D2S44) t o chromosome 2q13-q24.