CF2603 4DELT, A NEW FRAMESHIFT MUTATION IN EXON-13 OF THE CYSTIC-FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) GENE/

By using temperature gradient gel electrophoresis to screen for mutati ons in cystic fibrosis (CF) patients, we have found a new mutation in the CF transmembrane conductance regulator gene. It is a frameshift mu tation named CF2603/4delT located at the 3'-end of exon 13. A thymidin e at position 2603 or 2604 is lost. The mutation eliminates an MseI si te and, therefore, can be screened by restriction enzyme analysis.