COMPARISON OF RESULTS AFTER TRANSANAL ENDOSCOPIC MICROSURGERY AND RADICAL RESECTION FOR T1 CARCINOMA OF THE RECTUM

Background: We compared the results of transanal endoscopic microsurge ry and radical surgery in patients with T1 carcinomas of the rectum. M ethods: We performed a retrospective study (1985-96) to compare the re sults obtained in 103 patients with T1 rectal carcinomas (low-risk T1, n = 80; high-risk T1; n = 23) undergoing transanal endoscopic microsu rgery and radical surgical therapy. Results: The complication rate in patients undergoing local excision was 3.4% (two of 58); it was 18% (e ight of 45) in the group treated with radical surgery. Two of 45 patie nts (3.8%) died after radical resection; there were no deaths after lo cal excision, With regard to the actuarial 5-year survival rate, no di fference was observed in the group with low-risk T1 carcinoma between patients treated with local excision (79%) and those who had radical r esection (81%) (p = 0.72). Tn patients with high-risk T1 carcinoma, ly mph node metastases were identified in four of 11 patients undergoing radical resection (36%), Four of 12 patients with high-risk T1 carcino ma treated by local excision developed recurrences, whereas none of th e patients undergoing primary radical surgery had a recurrence. Conclu sions: Transanal endoscopic microsurgery for the treatment of low-risk T1 carcinomas is associated with a significantly lower complication r ate than radical surgical therapy. There is no difference in 5-year su rvival between local and radical surgical therapy in patients with low -risk T1 carcinoma.