The Fitch & Denenberg target article focuses almost exclusively on sho
rt gestation mammals, which differ substantially from long-gestation m
ammals in the timing and type of hormonal contribution to their sexual
differentiation. Conclusions regarding the role of ovaries in female
sexual differentiation may accordingly apply to only a limited number
of species. Specific criticisms of the organizational effects of hormo
nes stem from an incomplete reading of the original literature. The me
chanisms proposed in this target article reflect an extension of the p
rinciple of hormonal organization, not a revolutionary restructuring.