TECHNETIUM COMPLEXES - THEIR POSSIBLE USE IN RADIOPHARMACY AND PHARMACOKINETIC PROPERTIES

Tc-99m is the most widely used radionuclide in the nuclear medicine. C hemistry of the coordination compounds of Tc is given a permanent extr aordinary attention in connection with the continued development of ne w radiopharmaceutical preparations for diagnostics. Stability, structu re and lipophilicity of Tc complexes with ligands allowing for selecti ve functional representation and organ distribution is studied with re gard to the expected pharmacokinetic properties. Citrate ions, iminoac etate chelating groups, diphosphonate, mercaptoacetylglycinate, dimerc aptosuccinate, hexamethylpropyleneaminoxime, methoxy-iso-butylnitrilo, ethylenedicysteine, and isocyanide ligands were studied in Tc complex es as ligands or complete chelating groups. The possible diagnostic ap plications of individual complexes is indicated. The survey of labelle d Tc compounds for the verified diagnostic applications is given.