EFFECT OF GAMMA-RADIATION ON THE SN(II) CONTENT, RADIOCHEMICAL PURITY, IN-VITRO STABILITY AND BIOLOGICAL DISTRIBUTION OF SOME TC-99M-LABELED FREEZE-DRIED KITS

Gamma-irradiation can be used for the sterilization of some Tc-99m-lab elled freeze dried kits. in connection with this the effect of gamma-r adiation on Sn(II) content, radiochemical purity, in-vitro stability a nd biological distribution of some currently used Tc-99m-labelled kits has been investigated. For irradiation the certain radiation steriliz ation doses (25 and 50 kGy) were used. A variable decrease of Sn(II) c ontent was observed in all gamma-irradiated kits. The losses are in th e order of 10-25% compared with die Sn(II) content of original ones. T he colour of the irradiated kits did not changed except DTPA which dev eloped yellow colour after irradiation. For the irradiated and origina l kits nearly the same pH were found. The irradiated kits seemed to un dergo partial decomposition or chemical alteration which led to some d eviation of the biological distribution of them.