RADIOSENSITIZATION OF THYMINE BY FE(III)-1,2 DIHYDROXYANTHRAQUINONE COMPLEX IN DILUTE AQUEOUS-SOLUTION

Authors
DAS S SAHA A MANDAL PC
Citation
S. Das et al., RADIOSENSITIZATION OF THYMINE BY FE(III)-1,2 DIHYDROXYANTHRAQUINONE COMPLEX IN DILUTE AQUEOUS-SOLUTION, Journal of radioanalytical and nuclear chemistry, 196(1), 1995, pp. 57-63
Citations number
31
Categorie Soggetti
Chemistry Analytical","Nuclear Sciences & Tecnology","Chemistry Inorganic & Nuclear
Journal title
Journal of radioanalytical and nuclear chemistry → ACNP
ISSN journal
02365731
Volume
196
Issue
1
Year of publication
1995
Pages
57 - 63
Database
ISI
SICI code
0236-5731(1995)196:1<57:ROTBFD>2.0.ZU;2-D
Abstract
A complex of Fe(III) with 1,2 dihydroxy 9,10, anthraquinone (DHA) has been prepared. The metal ion forms a 1:3 complex with DHA. The complex is formed due to the dissociation of one proton per ligand bound to t he metal ion. The stability constant of the Fe(III) complex is 1.61 . 10(32). The complex reduces the catalytic flow of electrons from NADH to molecular O-2 through NADH dehydrogenase over DHA. The Fe(III) comp lex is seen to be an efficient radiosensitizer towards gamma-radiation induced degradation of thymine in a nitrous oxide saturated medium.