FAMILIAL CONGENITAL HORIZONTAL GAZE PARALYSIS AND KYPHOSCOLIOSIS

Congenital horizontal gaze paralysis is a rare disorder which may be a ssociated with severe scoliosis of early onset. We present the clinica l findings of two sisters with this syndrome. The additional finding o f a unique pericentric inversion of chromosome 12 is considered to be incidental. Every child with congenital horizontal gaze paralysis shou ld be evaluated for a possibly associated scoliosis. If present, a dia gnosis of this presumably autosomal recessive syndrome can be made wit h appropriate treatment and genetic counseling.