FUSE-BINDING PROTEIN IS DEVELOPMENTALLY-REGULATED AND IS HIGHLY EXPRESSED IN MOUSE AND CHICKEN EMBRYONIC BRAIN

GAP-43 modulates axon guidance and neuronal plasticity. In vitro, FUSE -binding protein (FBP) binds to a segment of GAP-43 mRNA which regulat es the stability of the transcript. FBP has also been shown to bind to a c-myc cis element and regulate transcription. In the current work, analysis of RNA and protein expression indicated that FBP is expressed in a distinct spatial temporal pattern during embryonic development. Expression was particularly high in the brain. In the adult, expressio n was not detected in most tissues but was still prominent in the brai n and teste. This finding is consistent with a dual role of the protei n as a single-strand polynucleotide-binding protein. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.