TIME-COURSE OF IMMUNOLOGICAL MARKERS IN PATIENTS WITH THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME - EVALUATION OF SCD14, SVCAM-1, SELAM-1, MIP-1-ALPHA AND TGF-BETA-2

Background The systemic inflammatory response syndrome (SIRS) is viewe d as a systemwide inflammatory response. Up until now, no parameter ha s been available for predicting the development of septic shock. In th e present study, we evaluated the usefulness of serum levels of CD14, vascular cell adhesion molecule-1 (VCAM-1), endothelial leucocyte adhe sion molecule-1 (ELAM-1), macrophage inflammatory protein (MIP) 1 alph a and transforming growth factor beta(2) (TGF-beta(2)) as early marker s of outcome in patients with SIRS. Methods A group of 28 SIRS patient s (13 survivors/15 non-survivors) was compared with a healthy control group and with patients with local inflammation. Blood samples were an alysed on days 0, 4 and 7. Proinflammatory parameters such as sCD14, s VCAM-1, sELAM-1, MIP-1 alpha and anti-inflammatory parameters such as TGF-beta(2) were determined using enzyme-linked immunosorbent assay (E LISA).Results At the beginning, all evaluated proinflammatory immunolo gical parameters with the exception of sVCAM-1 were significantly incr eased in patients with SIRS compared with the healthy control group. H owever, no significant difference could be observed for all immunologi cal parameters comparing survivors and non-survivors, with the excepti on of interleukin (IL) 6 at day 7. Conclusion All evaluated proinflamm atory parameters were increased in patients with SIRS during the cours e of the disease. However, the parameters have no correlation with out come and prognosis of SIRS patients.