In one couple investigated because of recurrent abortions, the female
was found to have an unusual translocation between the long arm of the
telomeric region of chromosome 12 and the long arm of the chromosome
14 at band q11. We studied ten additional members of the family who we
re under the risk: of the same chromosomal rearrangement, and four of
them were found to be carriers. The diagnosis of this translocation wa
s determined using different banding techniques and FISH. The karyotyp
e was found to be 45,XX,t(12;14)(qtel;q11).