SEQUENTIAL CLOMIPHENE CITRATE AND HUMAN MENOPAUSAL GONADOTROPIN WITH INTRAUTERINE INSEMINATION - THE EFFECT OF PATIENT AGE ON CLINICAL OUTCOME

The purpose of this investigation was to examine the influence of fema le and male patient age on pregnancy rates with sequential clomiphene citrate (CC) and human menopausal gonadotrophin (HMG) ovulation induct ion with intrauterine insemination (IUI) therapy after previous CC and IUI treatment failure. A total of 208 patients previously unable to c onceive with CC/IUI therapy underwent 416 treatment cycles of sequenti al CC/HMG with IUI at a university fertility centre between May, 1991 and August, 1995, Clinical pregnancy rates, live birth rates, and the effect of female and male partner chronological age were retrospective ly examined. Treatment with sequential CC/HMG with IUI resulted in cli nical pregnancy rates ranging from 5.9 to 23.1% despite previous CC/IU I treatment failure. Clinical pregnancy rates, live birth rates, and c umulative pregnancy rates declined significantly in female patients gr eater than or equal to 35 years of age compared to those <35 years of age. A statistically significant decline in clinical pregnancy rates c ould not be demonstrated as a function of increasing male partner age. Pregnancy rates in patients undergoing ovulation induction with seque ntial CC/HMG with IUI decline significantly with increasing female par tner age.