THE OUTCOME OF IN-VITRO FERTILIZATION TREATMENT BY EGG DONATION AND INTRACYTOPLASMATIC SPERM INJECTION FOR SEVERE MALE FACTOR INFERTILITY -A PRELIMINARY-REPORT

Due to a paucity of donated eggs, we have excluded, until recently, co uples with severe male factor infertility from our egg donation progra mme, except for those who accepted insemination with donor spermatozoa . The purpose of this study was to assess the feasibility of a shared in-vitro fertilization (IVF)-embryo transfer treatment whenever the re cipients have severe oligoasthenoteratozoospermia (OTA) and need intra cytoplasmic sperm injection (ICSI) for egg fertilization. The results from 163 consecutive couples with ovarian failure who underwent 273 cy cles of IVF with donated eggs and augmented with ICSI were analysed. T he rate of diploid fertilization was 54.7%; in 92.3% of the cycles, at least one embryo was available for transfer, Forty-seven clinical pre gnancies were achieved, representing 18.6% conceptions per transfer. T he highest pregnancy rate was achieved in menopausal patients aged 40- 45 years (26.2% per cycle) and the lowest in patients >45 years old (1 0.8% per cycle, P = 0.03), Overall, 28.8% of the couples achieved a cl inical pregnancy. A total of 196 treatment cycles resulted in 46 clini cal pregnancies (23.5%) among the donors. No statistical differences w ere found in pregnancy rate achieved by the donors when compared with the recipients. We conclude that ICSI with egg donation is a reliable treatment in patients with ovarian failure and severe OTA.