SYNTHESIS, STRUCTURE, AND BIOLOGICAL-ACTIVITIES OF SOME DIHYDRO-1H-IMIDAZOL-2-YL)-1,3-DIHYDROBENZIMIDAZOLE DERIVATIVES

A series of novel 4,5-dihydroimidazol-2-yl)-1,3-dihydrobenzimidazole d erivatives 2a-d, 3a-d and 4a-p were prepared and :their structure was determined by IR and NMR spectroscopic data as well as X-ray analysis of carbonitrile 2a. The compounds were studied as potential inhibitors of the human blood platelet aggregation:induced by adrenaline or ADP. Compounds of type 3 proved efficacious for the reduction of arterial blood pressure upon intra-venous: administration to normotensive rats.