INHERITANCE OF THE MAMMALIAN GOLGI-APPARATUS DURING THE CELL-CYCLE

The creation and propagation of the intricate Golgi architecture durin g the cell cycle poses a fascinating problem for biologists. Similar t o the inheritance process for nuclear DNA, the inheritance of the Golg i apparatus consists of biogenesis (replication) and partitioning (mit osis/meiosis) phases, in which Golgi components must double in unit ma ss, then be appropriately divided between nascent daughter cells durin g cytokinesis. In this article we focus discussion on the recent advan ces in the area of Golgi inheritance, first outlining our current unde rstanding of the behaviour of the Golgi apparatus during cell division , then concluding with a more conceptual discussion of the Golgi bioge nesis problem. Throughout, we attempt to integrate ultrastructural and biochemical findings with more recent information obtained using live cell microscopy and morphological techniques. (C) 1998 Elsevier Scien ce B.V. All rights reserved.