A. Kojima et al., LONG-LATENCY RESPONSE TO TRANSCRANIAL MAGNETIC STIMULATION IN PATIENTS WITH HEMIFACIAL SPASM, ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 109(4), 1998, pp. 285-289
Objective: We studied the long-latency response of the orbicularis ori
s muscle elicited with transcranial magnetic stimulation in patients w
ith hemifacial spasm (HFS) and evaluated the excitability of the facia
l nucleus. Methods: We compared the thresholds on both sides in 8 norm
al volunteers and 7 patients with hemifacial spasm. The thresholds wer
e determined as the lowest intensity required to produce motor evoked
potentials with an amplitude of at least 50 mu V in the orbicularis or
is muscle. Average values were given as means +/- standard deviation.
Wilcoxon's rank sum test was used for comparisons between the sides of
normal subjects and of patients with HFS with respect to the threshol
d stimulus. Results: There was no significant difference between the t
hresholds on the two sides of the normal subjects (mean 1.88 +/- 5.30%
, P > 0.05). In patients with HFS, there was a significant difference
between the thresholds on the spasm side and the normal side (mean 20.
7 +/- 13.0%, P < 0 05) In one patient studied after MVD, the differenc
e between both sides disappeared. Conclusion: The difference between t
he thresholds in patients with HFS and the normalization in threshold
after MVD suggested that the mechanism of HFS was hyperexcitability of
the facial nucleus. (C) 1998 Elsevier Science Ireland Ltd. All rights
reserved.