SYNTHESIS AND ADDUCTION OF FULLY DEPROTECTED OLIGODEOXYNUCLEOTIDES CONTAINING 6-CHLOROPURINE

Authors
KIM HY NECHEV L ZHOU LA TAMURA P HARRIS CM HARRIS TM
Citation
Hy. Kim et al., SYNTHESIS AND ADDUCTION OF FULLY DEPROTECTED OLIGODEOXYNUCLEOTIDES CONTAINING 6-CHLOROPURINE, Tetrahedron letters, 39(38), 1998, pp. 6803-6806
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
38
Year of publication
1998
Pages
6803 - 6806
Database
ISI
SICI code
0040-4039(1998)39:38<6803:SAAOFD>2.0.ZU;2-X
Abstract
Fully deprotected oligodeoxynucleotides containing 6-chloropurine have been synthesized and used in solution phase reactions with amine nucl eophiles to prepare oligonucleotides containing substituted adenine re sidues. This strategy was used for the preparation of a double-strande d oligonucleotide crosslinked by a 4-carbon tether between N-6 positio ns of deoxyadenosines in the two strands. (C) 1998 Elsevier Science Lt d. All rights reserved.