AN EFFICIENT ASYMMETRIC HYDROGENATION APPROACH TO THE SYNTHESIS OF THE CRIXIVAN(R) PIPERAZINE INTERMEDIATE

Authors
ROSSEN K PYE PJ DIMICHELE LM VOLANTE RP REIDER PJ
Citation
K. Rossen et al., AN EFFICIENT ASYMMETRIC HYDROGENATION APPROACH TO THE SYNTHESIS OF THE CRIXIVAN(R) PIPERAZINE INTERMEDIATE, Tetrahedron letters, 39(38), 1998, pp. 6823-6826
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
38
Year of publication
1998
Pages
6823 - 6826
Database
ISI
SICI code
0040-4039(1998)39:38<6823:AEAHAT>2.0.ZU;2-B
Abstract
The Crixivan(R) HIV protease inhibitor piperazine intermediate 2 was p repared by a four step sequence using a chiral hydrogenation of the te trahydropyrazine 9 to establish the absolute stereochemistry. (C) 1998 Elsevier Science Ltd. All rights reserved.