L. Elkaim et al., TRICHLOROACETIC-ACID HYDRAZONES I - NEW FORMATION OF 1,3,4-OXADIAZOLES FROM ALDEHYDES, Tetrahedron letters, 39(38), 1998, pp. 6885-6888
Trichloroacetic acid hydrazones, prepared from the condensation of car
bonyl derivatives with trichloroacetic acid hydrazide, display interes
ting chemical behaviour in the presence of a base. Aromatic and alpha,
beta-unsaturated aldehyde hydrazones in particular are easily transfor
med into 1,3,4 oxadiazoles derivatives. This original reaction represe
nts a new formal oxydation of aldehydes into acid derivatives in non o
xydative conditions, (C) 1998 Elsevier Science Ltd. All rights reserve
d.