SYNTHESIS AND PROPERTIES OF OLIGODEOXYRIBONUCLEOTIDES CONTAINING 4-N-ACETYLCYTOSINE BASES

Authors
WADA T KOBORI A KAWAHARA S SEKINE M
Citation
T. Wada et al., SYNTHESIS AND PROPERTIES OF OLIGODEOXYRIBONUCLEOTIDES CONTAINING 4-N-ACETYLCYTOSINE BASES, Tetrahedron letters, 39(38), 1998, pp. 6907-6910
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
38
Year of publication
1998
Pages
6907 - 6910
Database
ISI
SICI code
0040-4039(1998)39:38<6907:SAPOOC>2.0.ZU;2-7
Abstract
Oligodeoxyribonucleotides containing 4-N-acetyl-2'-deoxycytidines (ac( 4)dC) were synthesized by the H-phosphonate method. Thymidine 3'-O-(3, 3-dichloro)phthalate bound to a solid support was employed as the star ting material for the solid-phase synthesis. The (3,3-dichloro)phthalo yl (DCP) linker was found to be cleaved by treatment with 10% DBU in C H3CN for 5 min without loss of the 4-N-acetyl group of 2'-deoxycytidin e. The thermal stability of the duplexes containing ac(4)dC was invest igated. (C) 1998 Elsevier Science Ltd. All rights reserved.