Many host factors even in immunocompetent patients may have an influen
ce on development of a fungal diseases within the paranasal sinuses. F
ungal sinusitis can occur in an acute form or more often to a chronic
type of the disease. These mainly relatively asymptomatic chronic form
s are further divided into a chronic noninvasive, chronic allergic, an
d chronic invasive disease. Endonasal microsurgery has significantly c
hanged the management of chronic fungal sinusitis and allows adequate
removal of pathologic tissue even in advanced situations. The aim of t
his study was to analyze the efficacy of endonasal surgery in chronic
fungal sinusitis. Material and Methods: In a retrospective study we as
sessed a group of 40 patients who had endonasal surgery for chronic fu
ngal sinusitis. Patient records, CT and MRI scans, microbiology and hi
stology as well as the postoperative clinical follow-up including endo
scopic photo documentation were evaluated over a period of 5 years. Al
l patients underwent endonasal surgery using endoscopic techniques. Th
e microscope was of additional help in a few cases with extended disea
se and multiple dehiscences of the skull base. Results: Twenty-four pa
tients had a chronic noninvasive of fungal sinusitis and 16 patients h
ad a chronic invasive form. All these patients underwent endonasal sur
gery without external incision. The fungal disease was erradicated in
39 cases, and revision surgery was required in only one case in which
involvement of the contralateral side was not initially detected. In t
wo cases scar tissue in the middle meatus was later excised but withou
t evidence of residual fungal disease. Only in 6 cases was antifungal
chemotherapy required, where the disease had spread into surrounding t
issue or the patient had severe symptoms. Conclusions: Endonasal micro
surgical techniques are today the appropriate approach for managing ch
ronic fungal sinus disease even in severe cases with radiologic eviden
ce of expansion or invasion of surrounding tissue. Additional antifung
al chemotherapy is only rarely indicated, specifically when the fungal
disease invades surrounding tissue.