PRENATAL TREATMENT OF CONGENITAL ADRENAL-HYPERPLASIA

Prenatal diagnosis of congenital adrenal hyperplasia (CAH) is accurate and prenatal therapy is effective in significantly reducing or even e liminating virilization of females affected by CAH, sparing these chil dren the consequences of genital surgery, sex missassignment and gende r confusion. However, both the physical and psychological development of these children and the possibility of long-range adverse effects in the mothers need to be evaluated further. Prospective multicentre stu dies covering several decades are being designed.