GENETIC CONTRIBUTION TO MALE-INFERTILITY

Worldwide, of couples trying for a child, 2-7% fail to conceive, Exten sive screening programmes of men attending infertility clinics show th at chromosomal and gene disorders make a significant contribution to s permatogenic impairment, It appears that an orderly genome is essentia l for normal germ cell development, since numerical and structural chr omosome abnormalities are found in association with germ cell breakdow n, The most recent research indicates that genes on the Y chromosome a nd autosomes are involved in spermatogenic control.