A COMPARATIVE-STUDY ON THE EFFICACY OF THE NEW QUINOLONE ALATROFLOXACIN IN THE TREATMENT OF EXPERIMENTAL LEGIONELLOSIS IN GUINEA-PIGS

The in vivo efficacy of trovafloxacin, intraperitoneally administered as alatrofloxacin (CP-116,517), was assessed and compared with that of erythromycin, alone or in combination with rifampicin, in a model of Legionella pneumophila pneumonia in guinea pigs. Trovafloxacin (5 mg/k g administered as alatrofloxacin once daily for 7 days) gave a surviva l rate of 100% in infected animals. Clearance of bacteria and of bacte ria-induced lesions from lungs was achieved by day 6 postinoculation. The lungs of trovafloxacin-treated animals remained free of bacteria a t day 28 post-challenge. Trovafloxacin proved as effective as erythrom ycin administered intraperitoneally, but was superior to erythromycin alone, or in combination with rifampicin, when given orally.