We monitored 32 flight crewmembers before, during, and after 4-9 d com
mercial long-haul trips crossing up to 8 time zones per 24 h. The aver
age duty day lasted 9.8 h, and the average layover 24.8 h. Layover sle
ep episodes averaged 105 min shorter than pretrip sleep episodes. Howe
ver, in two-thirds oi layovers, crewmembers slept twice so that their
total sleep per 24 h on trips averaged 49 min less than pretrip. Great
er sleep loss was associated with nighttime flights than with daytime
fights. The organization oi layover sleep depended on prior fight dire
ction, local time, and the circadian cycle. The circadian temperature
rhythm did not synchronize to the erratic environmental time cues. Con
sequently, the circadian low point in alertness and performance someti
mes occurred in flight. On trip days, by comparison with pretrip, crew
members reported higher fatigue and lower activation; drank more caffe
ine; ate more snacks and fewer meals; and there were marked increases
in reports oi headaches, congested nose, and back pain. Scheduling str
ategies and countermeasures to improve layover sleep, cockpit alertnes
s, and performance, are discussed.