PROLIFERATING CELL NUCLEAR ANTIGEN IMMUNOREACTIVITY AND THE PRESENCE OF P53 MUTATION IN BASALOID-SQUAMOUS CELL-CARCINOMA OF THE LARYNX

Basaloid squamous cell carcinoma (BSCC) is an aggressive variant of sq uamous cell carcinoma (SCC) that was first described in 1986. In the E nglish literature, only 28 cases of this histopathological entity have been reported in the larynx. Proliferative features of this infrequen t tumor were investigated by proliferating cell nuclear antigen immuno reactivity, and the presence of P53 mutation was also investigated in a series of 4 cases. BSCC was found to share similar features with reg ular SCC in terms of its proliferation rate and P53 mutation positivit y, as well as biological behavior and clinical outcome.