IN-VITRO PRODUCTION OF PROGESTERONE AND ESTRADIOL BY RAT GRANULOSA-CELLS REGULATED BY CABERGOLINE AND PROLACTIN

Authors
NEGISHI H FURUTA I USHIGOE K FUJIMOTO S KOIDE SS
Citation
H. Negishi et al., IN-VITRO PRODUCTION OF PROGESTERONE AND ESTRADIOL BY RAT GRANULOSA-CELLS REGULATED BY CABERGOLINE AND PROLACTIN, Endocrine research, 24(2), 1998, pp. 195-203
Citations number
23
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Endocrine research → ACNP
ISSN journal
07435800
Volume
24
Issue
2
Year of publication
1998
Pages
195 - 203
Database
ISI
SICI code
0743-5800(1998)24:2<195:IPOPAE>2.0.ZU;2-S
Abstract
Cabergoline (CG), a dopamine agonist, and prolactin (PRL) added in vit ro to isolated granulosa cells from immature rats cultured in serum-fr ee medium inhibited FSH-stimulated production of progesterone. The low est effective concentrations of CG and PRL were 10(-8)M and I ng/mL, r espectively. In combination, the inhibitory activities were additive. CG at 10(-8) M also suppressed estradiol production by isolated rat gr anulosa cells; whereas PRL did not. In conclusion, CG inhibits FSH-sti mulated progesterone and estradiol production by rat granulosa cells.